| Tuan Rumah | Tamu | Stadion | TV |
|---|
| 27/11/2010 | Aston Villa | Arsenal | Villa Park | |
| 27/11/2010 | Manchester United | Blackburn Rovers | Old Trafford | |
| 28/11/2010 | Newcastle United | Chelsea | St. James' Park | |
| 28/11/2010 | Tottenham Hotspur | Liverpool | White Hart Lane | |
| 27/11/2010 | Everton | West Bromwich Albion | Goodison Park | |
| 27/11/2010 | Fulham | Birmingham City | Craven Cottage | |
| 27/11/2010 | Stoke City | Manchester City | Britannia | |
| 27/11/2010 | West Ham United | Wigan Athletic | Boleyn Ground | |
| 27/11/2010 | Wolverhampton Wanderers | Sunderland | Molineux | |
| 27/11/2010 | Bolton Wanderers | Blackpool | Reebok | |
|
| 1 | Chelsea | 14 | 9 | 1 | 4 | 28-9 | 28 |
| 2 | Manchester United | 14 | 7 | 7 | 0 | 28-15 | 28 |
| 3 | Arsenal | 14 | 8 | 2 | 4 | 28-15 | 26 |
| 4 | Manchester City | 14 | 7 | 4 | 3 | 19-11 | 25 |
| 5 | Bolton Wanderers | 14 | 5 | 7 | 2 | 26-20 | 22 |
| 6 | Tottenham Hotspur | 14 | 6 | 4 | 4 | 21-19 | 22 |
| 7 | Sunderland | 13 | 4 | 7 | 2 | 15-13 | 19 |
| 8 | Stoke City | 14 | 6 | 1 | 7 | 18-18 | 19 |
| 9 | Liverpool | 14 | 5 | 4 | 5 | 16-17 | 19 |
| 10 | Newcastle United | 14 | 5 | 3 | 6 | 22-21 | 18 |
| 11 | Blackburn Rovers | 14 | 5 | 3 | 6 | 17-18 | 18 |
| 12 | Blackpool | 14 | 5 | 3 | 6 | 21-27 | 18 |
| 13 | Aston Villa | 14 | 4 | 5 | 5 | 15-20 | 17 |
| 14 | Birmingham City | 14 | 3 | 7 | 4 | 15-17 | 16 |
| 15 | West Bromwich Albion | 14 | 4 | 4 | 6 | 16-25 | 16 |
| 16 | Everton | 13 | 3 | 6 | 4 | 14-13 | 15 |
| 17 | Fulham | 14 | 2 | 8 | 4 | 14-17 | 14 |
| 18 | Wigan Athletic | 14 | 3 | 5 | 6 | 10-23 | 14 |
| 19 | Wolverhampton Wanderers | 14 | 2 | 3 | 9 | 14-25 | 9 |
| 20 | West Ham United | 14 | 1 | 6 | 7 | 11-25 | 9 |
